Recurrent Idiopathic Urticaria: Understanding Pathophysiology, Impact on Quality of Life, Comorbidities, and Advances in Treatment

Title

Recurrent Idiopathic Urticaria: Understanding Pathophysiology, Impact on Quality of Life, Comorbidities, and Advances in Treatment

Author

1. Apurva Lodha, Student, Stony Brook University, United States

Abstract

Recurrent idiopathic urticaria (RIU), a chronic condition affecting approximately 1% of the global population, remains a significant burden, impairing patients' quality of life and leading to multiple comorbidities. Characterized by spontaneous and unpredictable hives and angioedema, RIU can persist for weeks or months, often without an identifiable cause. This paper reviews the pathophysiology of RIU, its effect on patients' physical and mental health, common comorbidities, and current treatment strategies. We also explore recent advances in treatment options and the future of personalized medicine for managing RIU, underlining the urgent need for targeted therapies and improved patient care.

Keywords

Conclusion

Recurrent idiopathic urticaria is a complex, chronic condition that significantly impacts patients' quality of life and is often associated with multiple comorbidities. While advancements in biological therapies, such as omalizumab, have improved treatment outcomes for many patients, there remains a need for more targeted therapies and personalised approaches to care. Further research into the pathophysiology of RIU and the development of new treatments will be critical in providing better care for patients with this challenging condition.

Author Contrubution

The author confirms sole responsibility for the following: study conception and design, data collection, analysis and interpretation of results, and manuscript preparation.

Funding

The authors did not receive any specific grants from funding agencies in the public, commercial, or non-profit sectors for the research, authorship, and/or publication of this article.

Conflict of Interest

All authors declare that they have no conflicts of interest.

Data Sharing Statement

Not applicable.

Software And Tools Use

Not applicable.

Acknowledgements

I thank the following individuals for their expertise and assistance in all aspects of our study and for their help in writing the manuscript. I am also grateful for the insightful comments given by anonymous peer reviewers. Everyone's generosity and expertise have improved this study in myriad ways and saved me from many errors.