Paleozoology, also spelled as Paleozoology is the branch of paleontology, paleobiology, or zoology dealing with the recovery and identification of multicellular animal remains from geological (or even archeological) contexts, and the use of these fossils in the reconstruction of prehistoric environments and ancient ecosystems.

Definitive, macroscopic remains of these metazoans are found in the fossil record from the Ediacaran period of the Neoproterozoic era onwards, although they do not become common until the Late Devonian period in the latter half of the Paleozoic era.

Perhaps the best known macrofossils group is the dinosaurs. Other popularly known animal-derived macrofossils include trilobites, crustaceans, echinoderms, brachiopods, mollusks, bony fishes, sharks, Vertebrate teeth, and shells of numerous invertebrate groups. This is because hard organic parts, such as bones, teeth, and shells resist decay, and are the most commonly preserved and found animal fossils. Exclusively soft-bodied animals—such as jellyfish, flatworms, nematodes, and insects—are consequently rarely fossilized, as these groups do not produce hard organic parts.

Vertebrate paleozoology refers to the use of morphological, temporal, and stratigraphic data to map vertebrate history in evolutionary theory. Vertebrates are classified as a subphylum of Chordata, a phylum used to classify species adhering to a rod-shaped, flexible body type called a notochord. They differ from other phyla in that other phyla may have cartilage or cartilage-like tissues forming a sort of skeleton, but only vertebrates possess what we define as bone.

Classes of vertebrates listed in chronological order from oldest to most recent include heterostracans, osteostracans, coelolepid agnathans, acanthodians, osteichthyan fishes, chondrichthyan fishes, amphibians, reptiles, mammals, and birds. All vertebrates are studied under standard evolutionary generalizations of behavior and life process, although there is controversy over whether population can be accurately estimated from limited fossil resources