TY - M-10059
AU - Bendahia, Abla
TI - An Instance of Radiation-Related Vertebral Displacement Fracture Simulating Solitary Bones Lung Cancer Metastatic Development
T2 - Scientific Research Journal of Medical and Health Science

PY - 2023
VL - 1
IS - 2
SN - 2584-1521

AB - The
critical role of pharmaceuticals and radiotherapy in lung cancer management
cannot be overstated. Despite the well-documented adverse effects of
electromagnetic radiation, identifying them can often be a complex task. In a
particular case, a male patient aged 58 was diagnosed with stage III squamous
cell lung cancer, categorized as cT1aN2M0. His treatment regimen included a
combination of biweekly chemotherapy using carboplatin and cisplatin over a
six-week period, accompanied by a course of 80 Gy distributed across 30
sessions of thoracic radiotherapy. This was followed by bi-monthly
administration of durvalumab over the course of a year.At the
conclusion of this durvalumab cycle, the patient complained of back discomfort.
The cause was determined by magnetic resonance imaging to be a break caused by
compression at the sixth thoracic spine. 
Further imaging with a CT scan and chlorine-17 fluorodeoxyglucose PET
scan indicated minimal uptake at the seventh thoracic vertebra, suggesting a
potential for bone metastasis. However, this was not supported by a
laparoscopic biopsy, which found no malignant cells. It was ultimately
determined that a radiation-induced fracture was responsible for the symptoms,
particularly since the fracture was located within the irradiated area near the
seventh cervical vertebra. After the
patient underwent surgery, a dual-energy X-ray absorptiometry scan revealed
osteopenia in the spine. Initially, pre-surgery imaging had hinted at bone
metastases, but ultimately, the postoperative biopsy was instrumental in
diagnosing a fracture related to the radiation treatment, ruling out metastasis
after the patient had undergone extensive chemotherapy and radiotherapy.

KW - lung cancer
KW -  chemotherapy
KW -  radiotherapy
KW -  durvalumab
KW -  bone metastasis
KW -  spinal fracture
DO -