@Article{M-10460,
AUTHOR = {Bernardes, Hiansen and Espoladori, Nicole},
TITLE = {Microbial Cell Factories for Sustainable Biomanufacturing: Advances in Metabolic Engineering, Synthetic Biology, and Industrial Applications},
JOURNAL = {Scientific Research Journal of  Biology and Life Science},
VOLUME = {3},
YEAR = {2025},
NUMBER = {2},
ARTICLE-NUMBER = {M-10460},
URL = {https://isrdo.org/journal/SRJBL/currentissue/microbial-cell-factories-for-sustainable-biomanufacturing-advances-in-metabolic-engineering-synthetic-biology-and-industrial-applications},
ISSN = {2584-0606},
ABSTRACT = {Microbial cell factories
have emerged as a transformative platform for the sustainable production of
chemicals, fuels, pharmaceuticals, and high-value biomolecules. By harnessing
the metabolic capabilities of microorganisms and combining them with modern
genetic engineering tools, researchers are able to convert renewable resources
into valuable products with high efficiency. Advances in metabolic engineering,
systems biology, and synthetic biology have significantly improved the
performance, robustness, and productivity of engineered microbial systems.
Microorganisms such as bacteria, yeast, and filamentous fungi are increasingly
used as bio-production hosts due to their rapid growth, genetic flexibility,
and ability to synthesize complex compounds. In recent years, innovations in
pathway optimization, genome editing, transcriptional control, and multiscale
engineering have enabled the construction of highly efficient microbial
platforms capable of industrial-scale biomanufacturing. Furthermore, microbial
cell factories contribute to environmental sustainability by reducing reliance
on fossil resources and minimizing industrial pollution. The integration of
computational modeling, omics technologies, and synthetic biology has further
expanded the potential of microbial engineering. This review provides a
comprehensive overview of the principles of microbial cell factory engineering,
the role of metabolic and synthetic biology approaches, and recent
technological advances that enhance product yield and industrial feasibility.
In addition, the review highlights emerging strategies for improving microbial
robustness and scalability while addressing the challenges associated with
industrial implementation. Overall, microbial cell factories represent a
promising strategy for achieving sustainable and eco-friendly biomanufacturing
in the modern bioeconomy.},
DOI = {}
}