@Article{M-10400,
AUTHOR = {Lin, Da and Rem, Sonavin},
TITLE = {Advances and Emerging Perspectives in Veterinary Stem Cell Therapy: Current Progress, Biological Challenges, and Future Clinical Directions},
JOURNAL = {Scientific Research Journal of Agriculture and Veterinary Science},
VOLUME = {3},
YEAR = {2025},
NUMBER = {2},
ARTICLE-NUMBER = {M-10400},
URL = {https://isrdo.org/journal/SRJAV/currentissue/advances-and-emerging-perspectives-in-veterinary-stem-cell-therapy-current-progress-biological-challenges-and-future-clinical-directions},
ISSN = {2584-1416},
ABSTRACT = {Stem-cell–based therapies have become one of the most rapidly advancing areas in veterinary regenerative medicine, offering promising alternatives for managing musculoskeletal injuries, neurological disorders, immune-mediated diseases, and various forms of tissue degeneration in both companion and farm animals. In recent years, notable progress has been made in the isolation, characterization, and therapeutic use of mesenchymal stromal/stem cells (MSCs), supported by improvements in cell culture methods, expanding clinical evidence, deeper molecular understanding, and growing awareness among veterinary practitioners.Early work established the clinical potential of MSCs for treating orthopedic and inflammatory conditions in animals, laying the foundation for today’s applications. More recent investigations have expanded this knowledge by examining cell morphology, proliferative capacity, cytogenetic stability, and overall safety during in vitro expansion, while also exploring new therapeutic possibilities across multiple animal species. Surveys of practicing veterinarians indicate increasing acceptance of stem-cell–based treatments, alongside clear gaps in knowledge, regulation, and clinical standardization. Additionally, insights from human medical research have enriched current understanding of immune modulation, tissue engineering, and translational challenges relevant to veterinary practice.This comprehensive review brings together progress across scientific, clinical, ethical, and practical dimensions of veterinary stem cell therapy. It identifies persistent limitations in standardization, long-term safety assessments, regulatory clarity, and practitioner training. It also highlights future directions that may shape the next era of veterinary regenerative medicine, including the integration of genomic editing, advanced biomaterials, data-driven treatment planning, and broader, well-designed clinical trials.},
DOI = {}
}