Phosphorus, potassium, and nitrogen, essential macronutrients, often pose the primary constraints in soil. They play a crucial role as supplementary factors in agricultural productivity. The production of nitrogen fertilizer in the cereal industry is primarily dedicated to three major crops: rice, wheat, and maize. Global food insecurity has become a pressing concern due to a growing population and shrinking farmland. While fertilizers have contributed to increased crop yields in the last six decades, their excessive application has had detrimental effects on the ecosystem. Inadequate use of fertilizers leads to reduced agricultural output, while excessive nitrogenous fertilizers negatively impact soil quality and the environment. Thus, adopting new approaches that preserve agricultural sustainability by achieving higher yields with reduced fertilizer usage and enhanced fertilizer use efficiency is imperative. This research aims to present methodologies that can effectively improve fertilizer use efficiency (FUE) to address this goal.